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The Genesis Mission, launched by the U.S. Department of Energy (DOE) in November 2025, aims to utilize artificial intelligence (AI) for scientific advancement. DOE's 17 national laboratories are set to leverage their substantial data streams and computing infrastructure for this initiative.

The mission outlines 26 science challenges, with funding details yet to be disclosed. SLAC National Accelerator Laboratory plans to use AI to analyze data from the Vera C. Rubin Observatory, which will generate 20 terabytes of data nightly.

Concerns about the initiative's funding and its lack of focus on climate change have been noted. DOE officials emphasize that while Genesis will drive AI research, it cannot tackle all scientific challenges alone.