IIT Collaborates with Uppsala University and AstraZeneca on Splicing Mechanism Study

A study by the Italian Institute of Technology (IIT), Uppsala University, and AstraZeneca explores the splicing mechanism fundamental to cellular function. Utilizing advanced computational chemistry and supercomputers, researchers simulated a molecular system of about two million atoms, enhancing the understanding of splicing dynamics. This research, supported by AIRC and the European High Performance Computing Joint Undertaking, could lead to new treatments for cancer and neurodegenerative diseases.

Published Mar 26, 2026

The Italian Institute of Technology (IIT) has partnered with Uppsala University and AstraZeneca to study the splicing mechanism essential for cellular function. The research, led by Marco De Vivo's Molecular Modeling and Drug Discovery unit, utilized advanced computational simulations on the supercomputer Franklin, analyzing a molecular system of approximately two million atoms.

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This study provides insights into the dynamics of the spliceosome, enabling researchers to interpret previously unclear biological data. The findings could facilitate the development of new therapeutic molecules targeting diseases such as cancer and neurodegenerative disorders, supported by AIRC and the European High Performance Computing Joint Undertaking.